Advanced esophageal squamous cell carcinoma (ESCC) is a serious and often challenging diagnosis, but recent clinical trials like AdvanTIG-203 are exploring promising new treatments such as ociperlimab and tislelizumab. These experimental therapies target immune checkpoint inhibitors to help the body’s defences fight cancer cells more effectively. While these developments are exciting, they also raise important questions for patients and their families about next steps, symptom management, and how to navigate complex care. If you or a loved one are dealing with oral or systemic symptoms related to cancer treatment—or if you’re a GP or dentist concerned about a patient’s oral health—understanding these advances can help guide informed decisions.
For patients with ESCC, symptoms can extend beyond the throat, often affecting oral health, nutrition, and overall quality of life. Persistent mouth ulcers, dry mouth (xerostomia), altered taste, or unexplained pain in the jaw or face may signal underlying issues that require specialist attention. These symptoms can be distressing, but early and accurate diagnosis—through secure telehealth consultations—can provide clarity and peace of mind without the need for unnecessary travel. Dr Suhaib Alqudah, Melbourne Oral Medicine’s specialist, is experienced in managing oral complications of systemic diseases, including those related to cancer therapies, ensuring patients receive tailored care from the comfort of home.
Esophageal squamous cell carcinoma (ESCC) is a type of cancer that begins in the squamous cells lining the esophagus. When diagnosed at an advanced stage, treatment options may include chemotherapy, radiation, immunotherapy, or clinical trials like AdvanTIG-203, which investigates combinations of immune checkpoint inhibitors—such as ociperlimab and tislelizumab—to improve survival rates and reduce tumour progression. These therapies work by blocking proteins that prevent the immune system from attacking cancer cells, potentially offering new hope for patients who have exhausted standard treatments.
Common symptoms of advanced ESCC include difficulty swallowing (dysphagia), persistent chest pain, unintended weight loss, and hoarseness. However, oral symptoms such as dry mouth, recurrent mouth ulcers, or unexplained pain in the jaw or face can also occur due to the cancer itself or its treatment. These symptoms may overlap with conditions like oral lichen planus, burning mouth syndrome, or xerostomia (a side effect of radiation or chemotherapy), which require careful assessment by an oral medicine specialist.
Cancer treatments, particularly radiation and chemotherapy, can have significant impacts on oral health. Radiation therapy to the head and neck region, for example, often leads to xerostomia (dry mouth), which is linked to increased risk of oral infections, tooth decay, and mucosal damage. Similarly, chemotherapy can cause severe oral mucositis—painful inflammation and ulceration of the mouth and throat—making eating and drinking difficult. These complications can further compromise nutrition and quality of life, making oral care a critical component of cancer management.
Patients undergoing immunotherapy, such as those trialled in AdvanTIG-203, may also experience immune-related side effects, including oral manifestations like stomatitis or lichenoid reactions. These symptoms can be distressing and may require intervention from an oral medicine specialist to ensure they do not escalate into more serious conditions. Early intervention—whether through telehealth consultations, prescription management, or referrals—can help mitigate these effects and improve patient comfort.
If you or a patient you’re referring are experiencing persistent oral symptoms—such as mouth ulcers that do not heal within two weeks, severe dry mouth, unexplained pain in the jaw or face, or changes in taste—it is important to seek evaluation. These symptoms could indicate an underlying oral mucosal disease, a side effect of cancer treatment, or even oral cancer itself. While some conditions, like oral lichen planus, are chronic and manageable, others may require urgent attention, such as a biopsy or referral to an oncologist.
An online consultation with Melbourne Oral Medicine allows for secure, convenient assessment without the need for in-person visits. During a telehealth appointment, Dr Alqudah can review symptoms, medical history, and any available imaging or blood test results to determine the next steps. This may include ordering additional tests, prescribing topical treatments for dry mouth or ulcers, or coordinating with your oncologist for a seamless care plan. Telehealth ensures you receive expert guidance while minimising unnecessary travel, particularly important for patients undergoing active cancer treatment.
At Melbourne Oral Medicine, we specialise in diagnosing and managing complex oral and maxillofacial conditions, including those related to systemic diseases like cancer. Our secure telehealth platform enables us to provide personalised care for patients across Australia, whether you’re dealing with dry mouth, recurrent ulcers, or pain related to your cancer treatment. By leveraging digital tools, we can:
Our approach prioritises early intervention and patient-centred care, helping you navigate the complexities of oral health during cancer treatment with confidence.
Yes, immunotherapy—including drugs like ociperlimab and tislelizumab—can cause immune-related side effects that may affect the mouth. These can include oral lichenoid reactions, stomatitis (inflammation of the mouth lining), or dry mouth. If you experience persistent oral symptoms during immunotherapy, it’s important to discuss them with your oncologist and an oral medicine specialist to manage them effectively.
Dry mouth (xerostomia) is a common side effect of radiation and chemotherapy, and it can be managed with artificial saliva, saliva substitutes, or prescription medications. An oral medicine specialist can recommend evidence-based strategies to alleviate symptoms, such as frequent hydration, sugar-free lozenges, or fluoride treatments to protect teeth. Telehealth consultations allow for personalised advice tailored to your specific treatment plan.
If your oral symptoms persist despite home care or over-the-counter treatments, it’s a good idea to consult an oral medicine specialist. Persistent dry mouth, ulcers, or pain could indicate an underlying condition that requires professional intervention. Telehealth makes it easy to seek expert advice without delay, ensuring you receive the care you need promptly.
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